Metastasis is the last step of a complex process in which a tumor cell leaves the primary tumor, penetrates the bloodstream and finally colonizes a distant organ.
So far, a collaboration between the team INSERM U1109 and a team from the IPCMS in Strasbourg has shown the influence of hemodynamics on attachment sites of tumor cells, using the zebrafish embryo as model.
HemoTum++ aims at building in silico models in order to better target the mechanisms involved.
- Rebuild the arterial/venous system of the zebrafish tail in 3D.
- Simulate the red blood cells and tumor cells flow in order to reproduce and extend in vivo and in vitro experiments.
- Model the chemical interactions between tumor cells and vessel walls and integrate them into the mechanical model.
We use Feel++ the flagship software of Cemosis for simulations.
Nouveaux arrivants dans l’équipe CEMOSISOctober 19, 2017
New preprint on the Hemotum++ projectOctober 4, 2017
Simulation of two-fluid flows using a finite element/level-set method in 3D. Application to two drop benchmarksJuly 22, 2016
- INSERM U1109, Université de Strasbourg
- Cemosis, Université de Strasbourg
- Liphy, Université Grenoble-Alpes,
- Labex IRMIA
- Thibaut Metivet (PostDoc)
- Francois Der Hovsepian (PhD)
- CNRS Défi Mecanobiologie 2018
- CNRS défi IMAG’IN 2016
- ANR Vivabrain
- Jacky Goetz
- Sébastien Harlepp
- Christophe Prud’homme