Summary
Metastasis is the last step of a complex process in which a tumor cell leaves the primary tumor, penetrates the bloodstream and finally colonizes a distant organ.
So far, a collaboration between the team INSERM U1109 and a team from the IPCMS in Strasbourg has shown the influence of hemodynamics on attachment sites of tumor cells, using the zebrafish embryo as model.
HemoTum++ aims at building in silico models in order to better target the mechanisms involved.
Goals
- Rebuild the arterial/venous system of the zebrafish tail in 3D.
- Simulate the red blood cells and tumor cells flow in order to reproduce and extend in vivo and in vitro experiments.
- Model the chemical interactions between tumor cells and vessel walls and integrate them into the mechanical model.
Software
We use Feel++ the flagship software of Cemosis for simulations.
Recent Posts
Nouveaux arrivants dans l’équipe CEMOSIS
October 19, 2017New preprint on the Hemotum++ project
October 4, 2017Simulation of two-fluid flows using a finite element/level-set method in 3D. Application to two drop benchmarks
July 22, 2016Collaboration
- INSERM U1109, Université de Strasbourg
- Cemosis, Université de Strasbourg
- Liphy, Université Grenoble-Alpes,
Funding
- Labex IRMIA
- Thibaut Metivet (PostDoc)
- Francois Der Hovsepian (PhD)
- CNRS Défi Mecanobiologie 2018
- CNRS défi IMAG’IN 2016
- ANR Vivabrain
Contacts
- Jacky Goetz
- Sébastien Harlepp
- Christophe Prud’homme
Team
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- Christophe Prud’homme (Professor)
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- Jacky Goetz (Research Director)
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- Sébastien Harlepp(Assistant Professor)
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- Mourad Ismail (Assistant Professor)
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- Vincent Chabannes
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- Thibaut Metivet (PostDoc)
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- François Der Hovsepian (PhD)
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- Gauthier Follain (PhD)
Images
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- vessel wall
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- Vessel architecture of the Zebra fish
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- Vessel architecture of the Zebra fish
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- Mesh of the vessel architecture of the Zebra fish
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- Mesh of the vessel architecture of the Zebra fish
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- blood flow for different treatments and at different ISV
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- Vessel wall geometry
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- Lumen geometry