Summary

Metastasis is the last step of a complex process in which a tumor cell leaves the primary tumor, penetrates the bloodstream and finally colonizes a distant organ.

So far, a collaboration between the team INSERM U1109 and a team from the IPCMS in Strasbourg has shown the influence of hemodynamics on attachment sites of tumor cells, using the zebrafish embryo as model.
HemoTum++ aims at building in silico models in order to better target the mechanisms involved.

Goals

  • Rebuild the arterial/venous system of the zebrafish tail in 3D.
  • Simulate the red blood cells and tumor cells flow in order to reproduce and extend in vivo and in vitro experiments.
  • Model the chemical interactions between tumor cells and vessel walls and integrate them into the mechanical model.

Software

We use Feel++ the flagship software of Cemosis for simulations.

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Collaboration

  • INSERM U1109, Université de Strasbourg
  • Cemosis, Université de Strasbourg
  • Liphy, Université Grenoble-Alpes,

Funding

  • Labex IRMIA
    • Thibaut Metivet (PostDoc)
    • Francois Der Hovsepian (PhD)
  • CNRS Défi Mecanobiologie 2018
  • CNRS défi IMAG’IN 2016
  • ANR Vivabrain

Contacts

  • Jacky Goetz
  • Sébastien Harlepp
  • Christophe Prud’homme

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